Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase
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چکیده
منابع مشابه
Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase
O(6)-Methylguanine (O(6)-meG) is a major mutagenic, carcinogenic and cytotoxic DNA adduct produced by various endogenous and exogenous methylating agents. We report the results of transcription past a site-specifically modified O(6)-meG DNA template by bacteriophage T7 RNA polymerase and human RNA polymerase II. These data show that O(6)-meG partially blocks T7 RNA polymerase and human RNA poly...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2008
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkn657